Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-12-19
1999-02-02
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514144, 536 111, 536117, 558156, 558160, 568883, A61K 3170, C07H 100, C07H 1104, C07H 1300
Patent
active
058665480
ABSTRACT:
Caged acyloxyalkyl esters of phosphate-containing inositol phosphates which are capable of permeating cell membranes. The second messengers are protected (caged) at the 6-hydroxyl, with a photolabile group. Once inside the cell, the ester derivatives undergo enzymatic conversion to remove the acyloxyalkyl ester groups. The resulting caged compound remains biologically inactive until exposed to ultraviolet (UV) light. Upon UV light exposure, the active form of the second messenger is released within the cell.
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Li Wenhong
Tsien Roger Y.
Crane L. Eric
Kight John
The Regents of the University of California
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