Caffeine salt complexes and methods for using the same in...

Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations – Aromatic acid or derivative containing

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S277100

Reexamination Certificate

active

08029770

ABSTRACT:
The present invention relates to pharmaceutical compositions containing a caffeine salt complex and a pharmaceutically acceptable carrier for use in methods for preventing or treating cancer or solar dermatitis. Methods for inducing apoptosis or inhibiting proliferation in a cancer cell or cell which as UVB-induced DNA damage using a caffeine salt complex or methylated xanthine are also provided.

REFERENCES:
patent: 3919413 (1975-11-01), Mebus
patent: 5656278 (1997-08-01), Enjolras
patent: 5922331 (1999-07-01), Mausner
patent: 6316435 (2001-11-01), Byrd et al.
patent: 6642274 (2003-11-01), Neal
patent: WO 98/23165 (1998-06-01), None
National Cancer Institute: Breast cancer prevention retrieved online Aug. 20, 2008 via http://www.cancer.gov/cancertopics/pdq/prevention/breast/Patient/page 3.
Medline Plus : Medical Encyclopedia: Ovarian cancer retrieved online on Aug. 20, 2008 via: https://www.nlm.nih.gov/medlineplus/ovariancancer.html, p. 1 dated on Jul. 31, 2008.
Zips et al. in vivo, 2005, 19:1-8.
Lu et al. (Oncol. Res. 2002; 13(2): 61-70).
Lu et al. (PNAS, 2002: 99(19), p. 12455-12460).
Fan et al., “Disruption of p53 Function Sensitizes Breast Cancer MCF-7 Cells to Cisplatin and Pentoxifylline”, Cancer Research 1995 55:1649-1654.
Huang et al., “Effects of Tea, Decaffeinated Tea, and Caffeine on UVB Light-induced Complete Carcinogenesis in SKH-1 Mice:Demonstration of Caffeine as a Biologically Important Constituent of Tea1”, Cancer Research 1997 57:2623-2629.
Koniaras et al., “Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells”, Oncogene 2001 20:7453-7463.
Lock et al., “Concentration-dependent Differences in the Mechanisms by Which Caffeine Potentiates Etoposide Cytotoxicity in HeLa Cells1”, Cancer Research 1994 54:4933-4939.
Lou et al., “Effects of Oral Administration of Tea, Decaffeinated Tea, and Caffeine on the Formation and Growth of Tumors in High-Risk SKH-1 Mice Previously Treated With Ultraviolet B Light”, Nutrition and Cancer 1999 33(2):146-153.
Lu et al., “Inhibitory effect of black tea on the growth of established skin tumors in mice:effects on tumor size, apoptosis, mitosis and bromodeoxyuridine incorporation into DNA”, Carcinogenesis 1997 18(11):2163-2169.
Lu et al., “Stimulatory Effect of Oral Administration of Green Tea or Caffeine on Ultraviolet Light-induced Increases in Epidermal Wild-Type p53, p21 (WAF1/CIP1), and Apoptotic Sunburn Cells in SKH-1 Mice1”, Cancer Research 2000 60:4785-4791.
Lu et al., “Topical applications of caffeine or (−)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice”, Proc. Natl. Acad. Sci. USA 2002 99(19):12455-12460.
Lu et al., “Inhibitory Effects of Orally Administered Green Tea, Black Tea, and Caffeine on Skin Carcinogenesis in Mice Previously Treated with Ultraviolet B Light (High-Risk Mice):Relationship to Decreased Tissue Fat1”, Cancer Research 2001 61:5002-5009.
Lu et al., “Stimulatory Effect of Topical Application of Caffeine on UVB-Induced Apoptosis in Mouse Skin”, Oncology Research/Anti-Cancer Drug Design 2002 13:61-70.
Nghiem et al., “ATR inhibition selectively sensitizes G1checkpoint-deficient cells to lethal premature chromatin condensation”, Proc. Natl. Acad. Sci. USA 2001 98(16):9092-9097.
Powell et al., “Differential Sensitivity of p53(−)and p53(+)Cells to Caffeine-induced Radiosensitization and Override of G2Delay1”, Cancer Research 1995 55:1643-1648.
Russell et al., “Preferential Radiosensitization of G1 Checkpoint Deficient cells by Methylxanthines”, Int. J. Radiation Oncology Biol. Phys. 1996 36(5):1099-1106.
Zajdela et al., “Inhibition of Skin Carcinogenesis In Vivo by Caffeine and Other Agents”, Natl. Cancer Inst. Monogr. 1978 50:133-140.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Caffeine salt complexes and methods for using the same in... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Caffeine salt complexes and methods for using the same in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Caffeine salt complexes and methods for using the same in... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4288770

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.