CAF1-related protein

Details CAF1-related protein CAF1-related protein

1998-02-20

2000-01-11

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 4352523, 4353201, 536 235, 536 2431, C12Q 168, C12P 2102, C12N 1512, C12N 1563

Patent

active

06013450&

ABSTRACT:
The invention provides a human CAF1-related protein (CAFRP) and polynucleotides which identify and encode CAFRP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of CAFRP.

REFERENCES:
Stryer, L., Biochemistry, W.H. Freeman and Company, New York, pp. 998-999 (1995).
Denis, C.L. and T. Malvar, "The CCR4 Gene From Saccharomyces cerevisiae Is Required for Both Nonfermentative and spt-Mediated Gene Expression", Genetics, 124: 283-291 (1990).
Malvar, T. et al., "The CCR4 Protein From Saccharomyces cerevisiae Contains a Leucine-Rich Repeat Region Which is Required for Its Control of ADH2 Gene Expression", Genetics, 132: 951-962 (1992).
Draper, M.P. et al., "CCR4 Is a Glucose-Regulated Transcription Factor Whose Leucine-Rich Repeat Binds Several Proteins Important for Placing CCR4 in Its Proper Promoter Context", Mol. Cell. Biol., 14: 4522-4531 (1994).
Draper, M.P. et al., "Identification of a Mouse Protein Whose Homolog in Saccharomyces cerevisiae Is a Component of the CCR4 Transctiptional Regulatory Complex", Mol. Cell Biol., 15: 3487-3495 (1995).
Sakai, A., "Molecular analysis of POP2 gene, a gene required for glucose-derepession of gene expression in Saccharomyces cerevisiae", Nuc. Acids Res., 20: 6227-6233 (1992).
Liu, H.Y. et al., "DBF2, a cell cycle-regulated protein kinase, is physically and functionally associated with the CCR4 transcriptional regulatory complex", EMBO J., 16: 5289-5298 (1997).
Latchman, D., Gene Regulation, Chapman and Hall, London, UK, pp. 242-255 (1995).
Draper, M.P. et al., (Direct Submission), GenBank Sequence Database (Accession 726136), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 726136) Feb. 12, 1996.
Draper, M.P. et al., (Direct Submission), GenBank Sequence Database (Accession U21855), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 726135; GI 726136) Feb. 14, 1996.
Hillier et al. (Sep. 30, 1997) GenBank, EST clone 743401. Accession No. AA609336. Accessed May 14, 1998, Sep. 1997.

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