Ca2+/calmodulin-dependent protein kinase IV

Details Ca2+/calmodulin-dependent protein kinase IV Ca2+/calmodulin-dependent protein kinase IV

2006-09-12

2006-09-12

Gitomer, Ralph (Department: 1654)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

C435S004000, C435S023000, C435S024000, C424S529000, C530S300000

Reexamination Certificate

active

07105312

ABSTRACT:
The present invention relates to Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) and, in particular, to methods of screening compounds for their ability to act as CaMKIV agonists or antagonists. The invention further relates to compounds identified using such methods and to therapeutic methodologies based on same.

REFERENCES:
patent: 6403352 (2002-06-01), Poovaiah et al.
patent: 6436656 (2002-08-01), Means
patent: WO 98/39412 (1998-09-01), None
Russell,J;Clinics inchest medicine;v7(2);pp189-200;(Jun. 1986) (Abstract Only).
Kitani et al, “Inactivation of Ca2+/Calmodulin-Dependent Protein Kinase IV by Ca2+/Calmodulin and Restoration of the Activity by Mg2+/EGTA”, J. Biochem. 117:1070-1075 (1995).

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