Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-06-06
2006-06-06
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S496000
Reexamination Certificate
active
07056913
ABSTRACT:
The present invention provides novel pyrrolo-[2,1-c][1,4]benzodiazepine hybrids useful as anti-tumour agents and a process for the preparation thereof.
REFERENCES:
patent: 0 098 098 (1984-01-01), None
patent: 00 12508 (2000-03-01), None
Kamal et al., Ahmed “Design, Synthesis, and Evaluation of New Noncross-Linking Pyrrolobenzodiazepine Dimers with Efficient DNA Binding Ability and Potent Antitumor Activity.” J. Med. Chem.. (2002), 45, pp 4679-4688.
Thurston et al., David E. “Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents.” J. Org. Chem. (1996), 61, pp. 8141-8147.
Schofield et al., Philip C. “Metabolism of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in cancer patients undergoing a phase I clinical trial.” Cancer Chemother Pharmacol (1999), 44, 51-58.
Gamage et al., Swarna A. “A New Synthesis of Substituted Acridine-4-carboxylic Acids and the Anticancer Drug N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA).” Tetrahedron Letters, (1997), 38, 4, pp. 699-702.
Thurston et al., David E. “Synthesis of DNA-Interactive Pyrrolo[2, 1-c][1,4]benzodiazepines.” Chem. Rev. (1994), 94, pp. 433-465.
Gujjar Ramesh
Kamal Ahmed
Olepu Srinivas
Poddutoori Ramulu
Pogula Praveen Kumar
Council of Scientific and Industrial Research
Kifle Bruck
Ladas and Parry LLP
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