Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-01-03
2006-01-03
McKelvey, Terry (Department: 1636)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S300000, C530S324000, C530S387100, C530S388100, C530S387900
Reexamination Certificate
active
06982317
ABSTRACT:
A gene in humans and mice, designated C21, encodes a family of proteins that play a role in transcriptional regulation. Two isoforms (α and β) produced by alternative splicing has been identified in humans. A transgenic model was created that shows that over-expression of C21 in mouse hematopoietic cells alters myeloid development and suggests that members of this family are involved in regulating stem cell differentiation. Over-expressing C21 in 3T3 fibroblasts increases their resistance to apoptotic stimuli. The C21 protein forms a complex with a class of molecules that plays a critical role in transcription, the co-repressors of nuclear hormone receptors.
REFERENCES:
Bassi et al, American Journal of Human Genetics, May 4, 1999, vol. 64, pp. 1604-1616.
Basch Ross S.
Zhang Xin-Min
Browdy and Neimark PLLC
McKelvey Terry
New York University
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