C2-fluoro pyrrolo [2,1− c ][1,4]benzodiazepine dimers

Details C2-fluoro pyrrolo [2,1− c ][1,4]benzodiazepine dimers C2-fluoro pyrrolo [2,1− c ][1,4]benzodiazepine dimers

2007-03-13

2007-03-13

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S496000

Reexamination Certificate

active

10812840

ABSTRACT:
The present invention relates to novel 2-fluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimers useful as antitumour agents and to a process for the preparation thereof.

REFERENCES:
patent: 9318045 (1993-09-01), None
Gregson et al., Stephen J. “Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity.” J. Med. Chem.. (2001), 44, pp. 737-748.
Thurston et al., David E. “Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1−c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents.” J. Org. Chem. (1996), 61, pp. 8141-8147.
Kamal et al., Ahmed “Design, Synthesis, and Evaluation of New Noncross-Linking Pyrrolobenzodiazepine Dimers with Efficient DNA Binding Ability and Potent Antitumor Activity.” J. Med. Chem. (2002), 45, 4679-4688.

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