C2-disubstituted indan-1-ones and their derivatives,...

Details C2-disubstituted indan-1-ones and their derivatives,... C2-disubstituted indan-1-ones and their derivatives,...

2006-07-25

2006-07-25

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S365000, C514S374000, C514S381000, C514S383000, C514S396000, C514S438000, C514S461000, C514S706000, C514S708000, C546S268100, C548S146000, C548S215000, C548S250000, C548S262200, C548S300100, C549S029000, C549S429000, C568S018000, C568S020000

Reexamination Certificate

active

07081467

ABSTRACT:
The present invention is directed C2-disubstituted indan-1-ones of the Formula I,physiologically acceptable salts, and physiologically functional derivatives thereof, and pharmaceutical compositions comprising such compounds, salts and derivatives, which are useful for reducing weight, for the prophylaxis or treatment of obesity, and for the prophylaxis or treatment of type II diabetes in mammals. The invention is directed also to methods for reducing weight and such treatments and prophylaxis. The invention is directed also to processes for the preparation of such compounds.

REFERENCES:
patent: 4063950 (1977-12-01), Fujiwhara et al.
patent: 4129656 (1978-12-01), Lang
patent: 4174397 (1979-11-01), Knabe
patent: 5232940 (1993-08-01), Hatton et al.
patent: 6090833 (2000-07-01), Jaehne
patent: 6159996 (2000-12-01), Jaehne
patent: 6235763 (2001-05-01), Jaehne
patent: 0234119 (1987-09-01), None
patent: 0295117 (1988-12-01), None
patent: 94/13643 (1994-06-01), None
patent: WO 97/20806 (1997-06-01), None
patent: WO 97/26265 (1997-07-01), None
patent: 97/32843 (1997-09-01), None
patent: WO 97/41097 (1997-11-01), None
patent: WO 98/08871 (1998-03-01), None
patent: 98/39302 (1998-09-01), None
patent: WO 98/55439 (1998-12-01), None
patent: WO 99/03861 (1999-01-01), None
patent: WO 01/12176 (2001-02-01), None
Russell et al, “Thermally cleavable safety-catch linkers for solid-phase chemistry.” Tetrahedron Letters (2000), vol. 41, pp. 5287-5290.
Russell et al, “Thermally cleavable safety-catch linkers for solid-phase chemistry.” Tetrahedron Letters (2000), vol. 41, pp. 5287-5290.
Copp, et al., Synthesis of 5,6,6a,7,7a,12a-Hexahydro-4H-benzo[d,e] benzothiano-[2,3-g] quinolines and 8-Phenyl-2,3,7,8,9,9a-hexahydro-1H-benzo[d,e] quinolines, J. Chem. Soc. Perkin Trans. I (1983), 909-914.
Rote Liste 2001, ECV Editio Cantor Verlag.
Edwards, D. et al., The Oxidation Of Alkyl Sulphides, J. Chem. Soc., 1954, pp. 3272-3274.
Lambert, P. D. et al., Ciliary Neurotrophic Factor Activates Leptin-Like Pathways And Reduces Body Fat, Without Cachaxia Or Rebound Weight Gain, Even in Leptin-Resistant Obesity, PNAS, Apr. 10, 2001, vol. 98, No. 8, pp. 4652-4657.
Maiti, A. K. et al., Polyethylene Glycol (PEG) 4000 Catalysed Regioselective Nucleophilic Ring Opening Of Oxiranas—A New And Convenient Synthesis Of Beta-Hydroxy Sulfone And Beta-Hydroxy Sulfide, Tetrahedron vol. 50, No. 35, pp. 10483-10490, 1994.
Monteiro, Hugo J. et al., A New Synthesis Of Beta-Keto-Phenylsulfoxides, Tetrahedron Letters No. 11, pp. 921-924, 1975.
Seebach, Dieter et al., Hers tallung Alpha-Thioilerter Carbonylverbindungen, Chem. Ber. 109, 1601-1616, 1976.
Sviridova, V. I. Leba et al., A Method For The Selective Oxidation Of Sulfides To Sulfoxides, J. Org. Chem (Russ), 7, pp. 2577-2580 (1971).
Tyle, Praveen, Iontophoretic Devices For Drug Delivery, Pharmaceutical Research, vol. 3, No. 6, 1986.
Venier, Clifford G. et al., Petroxytrifluoroacetic Acid. A Convenient Reagent For The Preparation of Sulfoxides And Sulfones, J. Org. Chem. 1982, 47, 3773-3774.

Affiliated with

Also associated with

Rating

C2-disubstituted indan-1-ones and their derivatives,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with C2-disubstituted indan-1-ones and their derivatives,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and C2-disubstituted indan-1-ones and their derivatives,... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3591487