C12-cyano epothilone derivatives

Details C12-cyano epothilone derivatives C12-cyano epothilone derivatives

2007-05-01

2007-05-01

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S204000

Reexamination Certificate

active

10386059

ABSTRACT:
The present invention relates to compounds useful in the treatment of cancer or other proliferative diseases represented by the formulawherein:R1, R2, R3, R4, R5are hydrogen or lower alkyl;R6is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or heterocyclo;X is hydrogen and Y is hydroxy, or X and Y taken together represent a carbon-carbon bond;and pharmaceutically acceptable salts, solvates, or hydrates thereof.Also included are therapeutic compositions containing the compounds represented by formula I as active ingredients, alone or in combination with other therapeutic agents useful in the treatment of cancer or other proliferative diseases.

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