C10 tricyclic taxanes

Details C10 tricyclic taxanes C10 tricyclic taxanes

1997-12-04

1999-12-07

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

549510, 549511, C07C27110, C07D30514

Patent

active

059986565

ABSTRACT:
Taxane derivatives having alternative C10 substituents.

REFERENCES:
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4876399 (1989-10-01), Holton et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 5015744 (1991-05-01), Holton
patent: 5136060 (1992-08-01), Holton
patent: 5175315 (1992-12-01), Holton
patent: 5200534 (1993-04-01), Rao
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 5243045 (1993-09-01), Holton et al.
patent: 5248796 (1993-09-01), Chen et al.
patent: 5250683 (1993-10-01), Holton et al.
patent: 5254580 (1993-10-01), Chen et al.
patent: 5254703 (1993-10-01), Holton
patent: 5264591 (1993-11-01), Bombardelli et al.
patent: 5272171 (1993-12-01), Ueda et al.
patent: 5294637 (1994-03-01), Chen et al.
patent: 5296506 (1994-03-01), Kingston et al.
patent: 5336785 (1994-08-01), Holton
patent: 5338872 (1994-08-01), Holton et al.
patent: 5350866 (1994-09-01), Holton et al.
patent: 5352806 (1994-10-01), Gunawardana et al.
patent: 5384399 (1995-01-01), Holton
patent: 5399726 (1995-03-01), Holton et al.
patent: 5405972 (1995-04-01), Holton et al.
patent: 5430160 (1995-07-01), Holton
patent: 5440056 (1995-08-01), Klein et al.
patent: 5478854 (1995-12-01), Farina et al.
patent: 5489601 (1996-02-01), Holton et al.
patent: 5530020 (1996-06-01), Gunawardana et al.
patent: 5532363 (1996-07-01), Holton
patent: 5539103 (1996-07-01), Holton
patent: 5556878 (1996-09-01), Kelly et al.
patent: 5594157 (1997-01-01), Gunawardana et al.
patent: 5614645 (1997-03-01), Kingston et al.
patent: 5616740 (1997-04-01), Klein et al.
patent: 5714513 (1998-02-01), Holton et al.
Holton et al., "A Synthesis of Taxusin", JACS 110:6558 (1988).
Wani et al., "Plant Antitumor Agents. VI. The Isolation and Structure of Taxol, A Novel Antileukemic and Antitumor Agent From Taxus Brevifolia", JACS 93:9, pp. 2325-2327 (May 05, 1971).
Holton, "Synthesis of the Taxane Ring System", JACS 106, pp. 5731-5732 (1984).
Mukerjee et al., ".beta.-Lactams: Retrospect and Prospect", Tetrahedron vol. 34, Report No. 52, pp. 1731-1767 (1978).
Science/Technology, "New Family of Taxol, Taxotere Analogs Developed", Chem & Engineering News, pp. 26-27 (Apr. 12, 1993).
Senilh et al., "Chime Organique Biologique-Hemisynthese de nouveaux analogues du taxol. Etude de leur interaction avec la tubuline", C.R. Acad. Sc. Paris, t. 299, Serie II, No. 15, pp. 1039-1043 (1984).
Ojima et al., "New and Efficient Approaches to the Semisynthesis of Taxol and its C-13 Side Chain Analogs by Means of .beta.-Lactam Synthon Method", Tetrahedron vol. 48, No. 34, pp. 6985-7012 (1992).
Denis & Green, "A Highly Efficient, Practical Approach to Natural Taxol", JACS, 110:5917-5919 (1988).
Farina et al., "The Chemistry of Taxanes: Unexpected Re-arrangement of Baccatin III During Chemoselective Debenzoylation With Bu3SnOMe/LiCl", Tetrahedron Letters, vol. 33, No. 28, pp. 3979-3982 (1992).
Klein, "Synthesis of 9-Dihydrotaxol: A Novel Bioactive Taxane" Tetrahedron Letters, vol. 34, No. 13, pp. 2047-2050 (1993).
Miller et al., "Antileukemic Alkaloids From Taxus Wallichiana Zucc", J. Org. Chem., vol. 46, No. 7, pp. 1469-1474 (1981).
Chen et al., "Taxol Structure-Activity Relationships: Synthesis and Biological Evaluation of 2-Deoxytaxol", Tetrahedron Letters, vol. 34, No. 20, pp. 3205-3206 (1993).
Molander et al., "Lanthanides in Organic Synthesis. 2. Reduction Of .alpha.-Heterosubstituted Ketones", J. Org. Chem., vol. 51, pp. 1135-1138 (1986).
Inanaga et al., "SmI2-Promoted Deacetoxylation of O-Acetyl-sugar Lactones. An Easy Access to Deoxysugar Lactones", Chem. Letters, pp. 1025-1026 (1991).
Kusada et al., "A Highly Efficient Deoxygenation of .alpha.-Oxygenated Esters VIA SmI2-Induced Electron Transfer Process 1", Tetrahedron Letters, vol. 30, No. 22, pp. 2945-2948 (1989).
Hanessian et al., "A Practical Synthesis of 2-Deoxy Aldono-lactones Via a SmI2-Mediated .alpha.-Deoxygenation Reaction", Tetrahedron Letters, vol. 33, No. 5, pp. 573-576 (1992).
A. Chaudhary et al., "Synthesis of 10-Deacetoxytaxol and 10-Deoxytaxotere" Deoxytaxotere Tetrahedron Letters, vol. 34, No. 31, pp. 4921-4924 (1993).
D. Kingston, "Progress in the Chemistry of Organic Natural Products" Springer-Verlag, Wien New York, p. 31 (1993).
G. Samaranayake et al., "Modified Taxols. 5.1 Reaction of Taxol with Electrophilic Reagents and Preparation of a Rearranged Taxol Derivative with Tubulin Assembly Activity" Journal of Organic Chemistry, 56:17, pp. 5114-5119 (1991).
Kingston et al. "The Chemistry of Taxol, a Clinically Useful Anticancer Agent" Journal of Natural Products, 53:1, pp. 1-12 (1990).
Mellado et al. "Preparation and Biological Activity of Taxol Acetates" Biochemical & Biophysical Research Communications, 124:2, pp. 329-336 (Oct. 30, 1984).
Magri et al. "Modified Taxols, 4. Synthesis and Biological Activity of Taxols Modified in the Side Chain" Journal of Natural Products, 51:2, pp. 298-306 (1988).

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