C10 carbamoyloxy substituted taxane compositions

Details C10 carbamoyloxy substituted taxane compositions C10 carbamoyloxy substituted taxane compositions

2007-06-12

2007-06-12

Owens, Amelia A. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S449000, C514S473000, C549S060000, C549S510000, C549S511000, C546S281700

Reexamination Certificate

active

11067882

ABSTRACT:
Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.

REFERENCES:
patent: 5175315 (1992-12-01), Holton
patent: 5227400 (1993-07-01), Holton et al.
patent: 5243045 (1993-09-01), Holton et al.
patent: 5283253 (1994-02-01), Holton et al.
patent: 5350866 (1994-09-01), Holton et al.
patent: 5430160 (1995-07-01), Holton
patent: 5556878 (1996-09-01), Kelly et al.
patent: 5567614 (1996-10-01), Patel et al.
patent: 5714513 (1998-02-01), Holton et al.
patent: 5721268 (1998-02-01), Holton et al.
patent: 5780653 (1998-07-01), Tao et al.
patent: 5811452 (1998-09-01), Ojima et al.
patent: 5879929 (1999-03-01), Patel
patent: 5906990 (1999-05-01), Bouchard et al.
patent: 5912264 (1999-06-01), Wittman et al.
patent: 6596737 (2003-07-01), Holton et al.
patent: 6638973 (2003-10-01), Holton
patent: 6909088 (2005-06-01), Noerenberg et al.
patent: 0 524 093 (1993-01-01), None
patent: 0 558 959 (1993-09-01), None
patent: 0 600 517 (1994-06-01), None
patent: 0 629 701 (1994-12-01), None
patent: WO 93/02065 (1993-02-01), None
patent: WO 93/23389 (1993-11-01), None
patent: WO 96/13495 (1996-05-01), None
patent: WO 97/09979 (1997-03-01), None
patent: WO 97/32578 (1997-09-01), None
patent: WO 97/42181 (1997-11-01), None
patent: WO 98/02426 (1998-01-01), None
patent: WO 99/09021 (1999-02-01), None
patent: WO 99/14209 (1999-03-01), None
patent: WO 99/32473 (1999-07-01), None
patent: WO 00/53592 (2000-09-01), None
patent: WO 01/57013 (2001-08-01), None
Terasawa,H et al ‘Preparation of baccatin III derivatives as antimors’ CA 126:60178 (1997).
Dubois, J. et al., “Fluorescent and Biotinylated Analogues of Docetaxel: Synthesis and Biological Evaluation”, Biorganic & Medicinal Chemistry, (1995), pp. 1357-1368, vol. 3:10.
Gueritte-Voegelein et al. “Relationships between the Structure of Taxol Analogues and Their Antimitotic Activity” Journal of Medicinal Chemistry, vol. 34, No. 3 (1991) pp. 992-998.
Kant et al. “A Chemoselective Approach to Functionalize the C-10 Position of 10-Deacetylbaccatin III. Synthesis and Biological Properties of Novel C-10 Taxol Analogues” Tetrahedron Letters, vol. 35, No. 30 (1994) pp. 5543-5546.
Kirikae et al. “Structural Significance of the Acyl Group at the C-10 Position and the A Ring of the Taxane Core of Paclitaxel for Inducing Nitric Oxide and Tumor Necrosis Factor Production by Murine Macrophages” FEBS Letters, vol. 478 (2000) pp. 221-226.
Ojima et al. “Synthesis and Biological Activity of Novel 3′-trifluoromethyl Taxoids” Bioorganic and Medicinal Chemistry Letters, vol. 7, No. 2 (1997) pp. 133-138.
Ojima et al. “Enantiopure Fluorine-containing Taxoids: Potent Anticancer Agents and Versatile Probes for Biomedical Problems” Journal of Fluorine Chemistry, vol. 97 (1999) pp. 3-10.
Ojima et al. “Synthesis and Structure-Activity Relationships of the Second-Generation Antitumor Taxoids: Exceptional Activity Against Drug-Resistant Cancer Cells” Journal of Medicinal Chemistry, vol. 39, No. 20 (1996) pp. 3889-3896.
Ojima et al., “Syntheses and Biological Activity of C-3′-Difluoromethyl-Taxoids” Bioorganic & Medicinal Chemistry, vol. 8 (2000) pp. 1619-1628.
Ojima et al. “Synthesis of Novel 3′-Trifluoromethyl Taxoids Through Effective Kinetic Resolution of Racemic 4-CF3-β-Lactams With Baccatins” Chirality, vol. 9 (1997) pp. 487-494.
Straubinger et al. “Pharmacology and Antitumor Effect of Novel Placlitaxel Formulations” Chapter 8, Edited by G. Georg et al., Taxane Anticancer Agents, Basic Science and Current Status, ACS Symposium Series 583, 207th National Meeting of the American Chemical Society, San Diego, CA (1994) pp. 111-123.
International Search Report from PCT/US01/03633 dated Jun. 11, 2001.

Affiliated with

Also associated with

Rating

C10 carbamoyloxy substituted taxane compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with C10 carbamoyloxy substituted taxane compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and C10 carbamoyloxy substituted taxane compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3874000