Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1991-08-20
1996-02-27
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4241851, 4241861, 4241991, 4242021, 4242041, 514 2, 435 693, 536 2372, 530350, 530826, A61K 3912, A61K 39295, C07K 1418
Patent
active
054946719
ABSTRACT:
The present invention relates to C-terminally truncated flavivirus envelope proteins 80-81% in size which are more immunogenic than their counterpart full-length proteins. The present invention further relates to recombinant viruses which encode the truncated protein and to host cells infected therewith. Host cells express the truncated protein on their outer membrane and secrete it into the medium. The present invention further relates to vaccines for use against flavivirus infection. The vaccines include either a recombinant vaccinia virus expressing the truncated envelope protein of the present invention, and the truncated envelope protein produced by a recombinant baculovinis.
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Bray Michael
Jan Lei-Ron
Lai Ching-Jun
Men Ruhe
Nucker Christine M.
The United States of America as represented by the Department of
Tuscan M. S.
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