C-terminal ketone inhibitors of matrix metalloproteinases and TN

Details C-terminal ketone inhibitors of matrix metalloproteinases and TN C-terminal ketone inhibitors of matrix metalloproteinases and TN

1997-12-17

1999-11-16

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514575, 546315, 548200, 548236, 548492, 548540, 549 72, 560 41, 562444, 562622, 562623, C07C25910, A61K 31165

Patent

active

059859113

ABSTRACT:
C-terminal compounds of formula ##STR1## are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.

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