C-terminal amide cyclic renin inhibitors containing peptide isos

Details C-terminal amide cyclic renin inhibitors containing peptide isos C-terminal amide cyclic renin inhibitors containing peptide isos

1986-10-07

1988-05-10

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, A61K 3743, C07K 512

Patent

active

047435844

ABSTRACT:
Cyclic renin-inhibitory peptides of the formula ##STR1## wherein G is an isostere component substituted into the substrate analogy at the cite of the enzyme cleavage, and analogs thereof, which inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.

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