C.sup.63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deox

Details C.sup.63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deox C.sup.63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deox

1992-05-20

1993-03-16

Chan, Y. Christina

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 530317, 530322, 530323, A61K 3702, C07K 750, C07K 900

Patent

active

051944243

ABSTRACT:
C.sup.63 -Amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin wherein the amide moiety is derived from a di- or poly-amine. The derivatives are prepared by reacting 34-de(acetylglucosaminyl)- 34-deoxy-teicoplanins with an active esters forming reagent such as chloroacetonitrile and then contacting the resulting active esters with the appropriate di- or poly-amine. The amide derivatives which are active against Gram-positive microorganisms, in particular against Group A Streptococci were found to be active also against bacteria which are resistant to glycopeptide antibiotics.

REFERENCES:
patent: 4542018 (1985-09-01), Borghi et al.
patent: 4638047 (1987-01-01), Szelke et al.

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