Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-12-02
1999-08-03
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514444, 514450, 514461, 546152, 549 60, 549368, 549429, A61K 31335, C07D32306
Patent
active
059325917
ABSTRACT:
Novel biologically-active 3-substituted trioxanes of the formula ##STR1## wherein R represents a substituted alkyl or aryl group of 1-20, preferably 1-12, carbon atoms, and methods for the use of biologically-active 3-substituted trioxanes of this formula as antiparasitic agents, particularly for the treatment of malaria.
REFERENCES:
patent: 4977174 (1990-12-01), Stein
patent: 5057501 (1991-10-01), Thornfeldt
patent: 5578637 (1996-11-01), Lai
patent: 5672624 (1997-09-01), Posner
Cope et al., Cyclic Polyolefins, . . . Cyclooctatetra-enes, J. Am. Chem. Soc. (1955) vol. 77, pp. 4939-4940.
Desjardins, et al., Quantitative Assessment . . . Technique, Antimicrobial Agents and Chemotherapy, Dec. 1979, pp. 710-718.
Milhous et al., In Vitro Activities . . . Antimalarial Drugs, Antimicrobial Agents and Chemotherapy, Apr. 1985, pp. 525-530.
Carmichael et al., Evaluation of a . . . Testing, Cancer Research 47, Feb. 15, 1987, pp. 936-942.
Fraser et al., Is Uracil . . . Treatment?, Biochemical & Biophysical Research Communications, vol. 135, No. 3, 1986, Mar. 28, 1986, pp. 886-893.
Posner, et al., Further Evidence . . . Like Artemisinin, J. of Medicinal Chemistry, vol. 38, No. 13, pp. 2273-2275.
Jiang et al., Antimalarial Activity of Mefloquine and Qinghaosu, The Lancet, Aug. 7, 1982, pp. 285-288.
Bruce-Chwatt, Qinghaosu: a new antimalarial, British Medical Journal, vol. 284, Mar. 13, 1982, pp. 767-768.
Klayman, Qinghaosu (Artemisinin): An Antimalarial Drug from China, Science, vol. 228, May 31, 1985, pp. 1049-1055.
Miyashi et al., Evidence for a Chair Cyclohexane 1,4-Radical Cation . . . of 2,5-Diaryl-11,5-hexadienes, J. Am. Chem. Soc. 1988, 110, pp. 3676-3677.
Miyashi et al., Photoinduced electron-transfer reactions of the cope and related systems, Pure & Appl. Chem., 1990, vol. 62, No. 8, pp. 1531-1538.
Takahashi et al., Electron-Transfer . . . 2,6-Diarylhepta-1,6-dienes, Tetrahedron Letters, 1994, vol. 35, No. 23, pp. 3953-3956.
Hudson, Atovaquone--A Novel Broad-spectrum Anti-infective Drug, Parasitology Today, vol. 9, No. 2, 1993, pp. 66-68.
Schmid et al., Total Synthesis of Qinghaosu, J. Am. Chem. Soc., 1983, 105, pp. 624-625.
Posner et al., U.S. Patent Appln. No. 08/701,423, filed Aug. 22, 1996.
Posner et al., Tetrahedron Letters 37:815-818 (1996).
Posner et al., Tetrahedron Letters 37:7225-7228 (1996).
Avery et al., J. Med Chem. 39: 2900-2906 (1996).
Posner et al., Heteroatom Chemistry 6: 105-116 (1995).
Posner et al., J. Amer. Chem. Soc. 118:3537-3538 (1996).
Cumming Jared N.
Posner Gary H.
Woo Soon Hyung
Johns Hopkins University
Oswecki Jane C.
Richter Johann
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