Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1991-08-09
1998-07-21
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
530327, 514 14, A61K 4505, A61K 3804, C07K 500
Patent
active
057831793
ABSTRACT:
Compounds having immunomodulatory activity comprising the optionally modified dodecapeptide fragment A-(SEQ ID No: 1)-B corresponding to residues 174 to 185 of C-reactive protein (CRP), pharmaceutical compositions thereof, and methods of treating cancer with the compositions. Liposomal formulations containing the CRP-peptide fragment are particularly efficacious when administered in conjunction with interleukin-2.
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FASEB J., (1989), 3:A831, S. Deodar, et al. Enhanced Anti-Tumor Effect by Combination Therapy with Human C-Reactive Protein (CRP) Peptide and IL2 in C57 Mice Bearing the Fibrosarcoma T241.
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Barna Barbara P.
Deodhar Sharad D.
Eppstein Deborah A.
Felgner Philip L.
Ho Teresa H.
Marshall S.
Syntex (U.S.A.) Inc.
Tsang Cecilia J.
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