C-peptide specific assay procedure

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007930, C435S007940, C435S070210, C435S331000, C435S336000, C435S962000, C435S975000, C436S518000, C436S536000, C436S548000, C530S387900, C530S388240, C530S389200, C530S845000

Reexamination Certificate

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06929924

ABSTRACT:
The present invention relates to a specific C-peptide assay method which can eliminate all interference due to proinsulin and its intermediates, in particular des-31,32-proinsulin and/or des-64,65-proinsulin. It also relates to antibodies for carrying out this assay.

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patent: 0484961 (1992-05-01), None
Dinesen et al., First assay specific for intact human proinsulin. Diabetologia 37 (Suppl. 1): A103, Abstract #400.
Madsen et al., 1984. Human proinsulin-specific antigenic determinants identified by monoclonal antibodies. Diabetes 33:1012-1016.
Hellstrom et al., 1985. InMonoclonal Antibodies for Cancer Detection and Therapy(Baldwin et al, eds.), Academic Press, London. p. 20.
Madsen et al., “The Production and Characterization of Monoclonal Antibodies Specific for Human Proinsulin Using a Sensitive Microdot Assay Procedure,”Endochrinology, 113(6):2135-2144 (1983).
Angelo et al., “A Highly Sensitive Monoclonal Antibody Against Human C-Peptide,”Diabetes Research and Clinical Practice, vol. Suppl. 1:S18-S19 (1985).
Reaven et al., “Plasma Insulin, C-Peptide, and Proinsulin Concentrations in Obese and Nonobese Individuals with Varying Degrees of Glucose Tolerance,”Journal of Clinical Endocrinology and Metabolism, 76(1):44-48 (1993).

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