C-nitroso-derived nitroxyl donors

Details C-nitroso-derived nitroxyl donors C-nitroso-derived nitroxyl donors

2011-08-02

2011-08-02

Witherspoon, Sikarl (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S109000, C568S949000, C514S533000, C514S741000

Reexamination Certificate

active

07989652

ABSTRACT:
Active compounds of Formula I are described:wherein: R1and R2are each independently C1-C4 alkyl; or R1and R2together form a C2-C7 alkylene chain; and Z is a non-steroidal anti-inflammatory drug (NSAID); along with pharmaceutically acceptable salts and prodrug thereof, and methods of using the same.

REFERENCES:
patent: 6680229 (2004-01-01), Nuttall et al.
patent: 6756408 (2004-06-01), Uretsky et al.
patent: 6946441 (2005-09-01), Long et al.
patent: 2005/0192254 (2005-09-01), Wink et al.
International Search Report and Written Opinion, PCT/US07/09160, mailed Jun. 3, 2008.
White EH and Considine WJ. The acylation of salts of secondary nitroparaffins. J. Amer. Chem. Soc. 1958; 80: 626-630.
Day JS et al. Appearance potential studies of some geminal substitutedC-nitroso-compounds. Journal of the Chemical Society, Perkins Transactions 2: Physical Organic Chemistry. 1978; 10: 1110-1112.
Sha X et al. Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO). J. Amer. Chem. Soc. 2006; 128: 9687-9692.
Daineko VI et al. [3,2]-sigmatropic rearrangement of acyloxy nitronic acids into geminal acyloxy nitroso compounds. Russian Journal of Organic Chemistry. 2002; 38(10): 1431-1433.
Wang PG et al. Nitric oxide donors: chemical activities and biological applications. Chem. Rev. 2002; 102(4): 1091-1134.
Zhutov EV et al.p-bromo(diacetoxyiodo)benzene, an efficient oxidant for conversion of oximes into nitroso compounds. Russian Journal of Organic Chemistry. 2003; 39(11): 1672-1673.
Engelhardt FC et al. Synthesis of a NO-releasing prodrug of rofecoxib. J. Org. Chem. 2006; 71(2): 480-491.
Rehse K and Herpel M. Azodioxides activated by electron acceptors in geminal or vicinal position. Arch. Pharm. Pharm. Med. Chem. 1998; 331: 104-110.
Kropf H and Lambeck R. Reactions with lead tetraacetate. 1. Geminal nitroso acyloxy alkanes and their dimmers. Justus Liebigs Annalen Der Chemie. Jan. 1, 1966; 700: 1-17.
Feelisch M. Nitroxyl gets to the heart of the matter. PNAS. Apr. 29, 2003; 100(9): 4978-4980.
Paolocci N et al. Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling. PNAS. Apr. 29, 2003; 100(9): 5537-5542.
Supplementary European Search Report, EP07755433, Dec. 13, 2010.

Affiliated with

Also associated with

Rating

C-nitroso-derived nitroxyl donors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with C-nitroso-derived nitroxyl donors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and C-nitroso-derived nitroxyl donors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2670931