Organic compounds -- part of the class 532-570 series – Organic compounds – Azoxy
Reexamination Certificate
2007-08-21
2007-08-21
Habte, Kahsay (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Azoxy
C514S231500, C514S230500, C514S250000, C514S252170, C514S645000, C514S214030, C514S356000, C514S396000, C514S411000, C514S415000, C514S471000, C514S166000, C514S211070, C568S949000, C540S552000, C546S329000, C546S124000, C548S444000, C548S503000, C548S530000, C548S452000, C548S337100, C544S133000, C544S091000, C544S295000, C544S350000, C544S366000
Reexamination Certificate
active
11052141
ABSTRACT:
A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. When the compound is obtained from a carbon acid with a pKa less than about 10, it provides vascular relaxing effect when used at micromolar concentrations and this activity is potentiated by glutathione to be obtained at nanomolar concentrations. When the compound is obtained from a carbon acid with a pKa ranging from about 15 to about 20, vascular relaxing effect is obtained at nanomolar concentrations without glutathione. In another embodiment, a biocompatible polymer incorporates a C-nitroso moiety.
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Stamler Jonathan S.
Toone Eric J.
Bacon & Thomas PLLC
Duke University
Habte Kahsay
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