C-nitroso compounds and use thereof

Details C-nitroso compounds and use thereof C-nitroso compounds and use thereof

2005-05-03

2005-05-03

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C540S470000, C540S484000, C540S544000, C540S553000, C540S612000, C544S003000, C544S063000, C544S224000, C548S206000, C548S240000, C548S356100

Reexamination Certificate

active

06887994

ABSTRACT:
A C-nitroso compound having a molecular weight ranging from about 225 to about 1,000 (from about 225 to about 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. In another case, the C-nitroso compound contains the moietyin-line-formulae description="In-line Formulae" end="lead"?—C—N(O)X—in-line-formulae description="In-line Formulae" end="tail"?where X is S, O or NR. One embodiment is directed to COX-2 inhibitors where a tertiary carbon atom and/or an oxygen atom and/or a sulfur atom is nitrosylated.

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