c-Met modulators and methods of use

Details c-Met modulators and methods of use c-Met modulators and methods of use

2009-02-26

2009-08-25

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S312000

Reexamination Certificate

active

07579473

ABSTRACT:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

REFERENCES:
patent: 6143764 (2000-11-01), Kubo et al.
patent: 7135466 (2006-11-01), Sakai et al.
patent: 7425564 (2008-09-01), Fujiwara et al.
patent: 2005/0049264 (2005-03-01), Miwa et al.
patent: 2008/0312221 (2008-12-01), Fujiwara et al.

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