c-MET kinase binding proteins

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S402000

Reexamination Certificate

active

07968681

ABSTRACT:
Polypeptides comprising monomer domains that bind to c-MET, or portions thereof, are provided.

REFERENCES:
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Database EPO Proteins [Online], “Sequence 85 from Patent WO0216600,” retrieved from EBI Accession No. EPOP: AX449750, Jul. 2, 2002 (1 page).
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Nielsen et al., Segments in the C-terminal Folding Domain of Lipoprotein Lipase Important for Binding to the Low Density Lipoprotein Receptor-related Protein and to Heparan Sulfate Proteoglycans,J. Biol. Chem., 272(9): 5821-5827 (1997).
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Maulik et al., “Role of the Hepatocyte Growth Factor Receptor, c-Met, in Oncogenesis and Potential for Therapeutic Inhibition,” Cytokine Growth Factor Reviews 13(1): 41-59 (2002).
Peschard et al., “Mutation of the c-Cbl TKB Domain Binding Site on the Met Receptor Tyrosine Kinase Converts It into a Transforming Protein,” Mol. Cell 8(5): 995-1004 (2001).

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