Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2004-07-02
2010-06-01
McIntosh, III, Traviss C (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S001110, C536S029200, C536S124000
Reexamination Certificate
active
07727965
ABSTRACT:
The present invention relates to C-Glycosylisoflavones having alkylaminoalkoxyl substituent and pharmaceutically acceptable salts thereof, a process for the preparation thereof, pharmaceutical compositions comprising an effective amount of a compound of the formula (I), and to the use of these compounds or compositions for the treatment or prevention of cardio- and cerebrovascular diseases, in particular for the treatment of various cardiocerebral hypoxic-ischemic diseases, for the treatment or prevention of diabetes mellitus and complications thereof, and for the treatment or prevention of chemical poisoning, in particular alcoholism.
REFERENCES:
patent: 1394603 (2003-02-01), None
patent: WO2004/002470 (2004-01-01), None
Gao et al. (Synthesis of Daidzin Analogues as Potential Agents for Alcohol Abuse), Bioorganic & Medicinal Chemistry, 2003, 4069-81, 11 (18).
Yang Ruolin, et al., “Preparation and Bio-activity of Puerarin Derivatives”, Journal of China Pharmaceutical University, 1999, vol. 30, No. 2, pp. 81-85, with English abstract (last page).
Hou , et al., “Study on the preparation of 7,4′-di-O-hydroxyethyl puerarin”, Chinese Journal of Medicinal Chemistry, Apr. 2002, vol. 12, No. 2, pp. 103-104, with English abstract (last page).
Guang-Yao Gao, et al., “Synthesis of Daidzin Analogues as Potential Agents for Alcohol Abuse,” Bioorganic & Medicinal Chemistry, 2003, vol. 11, pp. 4069-4081.
Wang Jing, et al., “Study Achievement of Puerarin,” 2003, vol. 27, No. 2, pp. 70-73, with English abstract.
Cheng Weijin, et al., “Survey on the Fever Caused by Kakonein Injection” 1995-2006 Tsinghua Tongfang Optical Disc Co., Ltd., 2000, 9(3); pp. 129-130, with English abstract.
Wu Zhenghong, et al., “Studies on the Solubility of Puerarin and the Solubilizing Effect of Polymer,” Tsinghua Tongfang Optical Disc Co., Ltd. (1995-2006) 1999, 7(1); pp. 10-11.
International Search Report dated Sep. 30, 2004 of corresponding PCT/CN2004/000728.
Che Fengsheng
Han Ling
Jin Yiguang
Li Lu
Lu Qiujun
Christie Parker & Hale LLP
Hainan Yangpu New & Special Medicine Co., Ltd.
Institute of Radiation Medicine, Academy of Military Medical Sci
McIntosh, III Traviss C
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