C-fms kinase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S422000, C546S214000, C548S517000

Reexamination Certificate

active

07429603

ABSTRACT:
The invention is directed to compounds of Formulae I, II and III:wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

REFERENCES:
patent: 3717579 (1973-02-01), Hofmann et al.
patent: 3862152 (1975-01-01), Kuwada et al.
patent: 4172947 (1979-10-01), Warner, Jr. et al.
patent: 4186199 (1980-01-01), Glamkowski et al.
patent: 5258357 (1993-11-01), Muenster et al.
patent: 5854285 (1998-12-01), Sriram et al.
patent: 6380247 (2002-04-01), Konishi et al.
patent: 6420567 (2002-07-01), Wu et al.
patent: 6545161 (2003-04-01), Gupta et al.
patent: 6936736 (2005-08-01), Ikeda et al.
patent: 7012094 (2006-03-01), Bertenshaw et al.
patent: 7019024 (2006-03-01), Ognyanov et al.
patent: 7037937 (2006-05-01), Uckun et al.
patent: 7041702 (2006-05-01), Durant et al.
patent: 7045551 (2006-05-01), Wu et al.
patent: 7087604 (2006-08-01), Cherney
patent: 7098240 (2006-08-01), Griffiths et al.
patent: 7105564 (2006-09-01), Honma et al.
patent: 7109243 (2006-09-01), Liu et al.
patent: 7115660 (2006-10-01), Boger et al.
patent: 7179840 (2007-02-01), Rieck et al.
patent: 2005/0004112 (2005-01-01), Player et al.
patent: 2005/0113566 (2005-05-01), Player et al.
patent: 2005/0131022 (2005-06-01), Player et al.
patent: 26 35 818 (1977-11-01), None
patent: 1 193 246 (2002-04-01), None
patent: 1 508 947 (1978-04-01), None
patent: WO 95/19169 (1995-07-01), None
patent: WO 02/28825 (2000-04-01), None
patent: WO 00/27820 (2000-05-01), None
patent: WO 00/62778 (2000-10-01), None
patent: WO 02/068406 (2002-09-01), None
patent: WO 03/103648 (2003-12-01), None
patent: WO 03/103658 (2003-12-01), None
patent: WO 2004/018461 (2004-03-01), None
patent: WO 2004/022525 (2004-03-01), None
patent: WO 2004/096795 (2004-11-01), None
patent: WO 2006/047277 (2006-05-01), None
patent: WO 2006/047504 (2006-05-01), None
CAS accerssion No. 1973:132353, Registry No. 41235-81-8.
Nilsson et al, J. Comb. Chem, vol. 3, pp. 546-553, 2001.
Dhanoa et al, “Serine Proteases-Directed Small Molecule Probe Libraries”, Medicinal Chemistry Research, vol. 8, No. 4/5 (1998) pp. 187-205 (XP009016618) ISSN: 1054-2523.
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 214943, BRN 214944, BRN 303350 (XP002378023).
Blankley et al, “Antihypertensive Activity of 6-Arylpyrido[2,3-d]pyrimidin-7-amine Derivatives. 2. 7-Acyl Amide Analogues”,Journal of Medicinal Chemistry, vol. 26, No. 3, Mar. 1, 1983, pp. 403-411, ISSN: 0022-2623 (XP002000852).
Chan et al, “Halogen Substitution at the Isoxazole Ring Enhances the Activity of N-(Isoxazolyl)sulfonamide Endothelin Antagonists”,Bioorganic&Medicinal Chemistry Letters, vol. 6, No. 20, 1996, pp. 2393-2398, ISSN: 0960-894X (XP002314441).
Contreras et al, “Aminopyridazines as Acetylcholinesterase Inhibitors”,Journal of Medicinal Chemistry, vol. 42, No. 4, Feb. 25, 1999, pp. 730-741, ISSN: 0022-2623 (XP002353008).
Moffett et al, “Antiulcer Agents. p-Aminobenzamido Aromatic Compounds”,Journal of Medicinal Chemistry, vol. 14, No. 10, Oct. 1971, pp. 963-968, ISSN: 0022-2623 (XP002057311).
Robert-Piessard et al, “Non-acidic Anti-inflammatory Compounds: Activity of N-(4,6-dimethyl-2-pyridinyl) Benzamides and Derivatives”,European Journal of Medicinal Chemistry, vol. 25, No. 1, 1990, pp. 9-19, ISSN: 0223-5234 (XP001062115).
Seydel et al, “Quantitative Structure-Pharmacokinetic Relationships Derived on Antibacterial Sulfonamides in Rats and Its Comparison to Quantitative Structure-Activity Relationships”,Journal of Medicinal Chemistry, vol. 23, No. 6, Jun. 1980, pp. 607-613, ISSN: 0022-2623 (XP002392659).
Stein et al, “Discovery and Structure-Activity Relationships of Sulfonamide EtA-Selective Antagonists”,Journal of Medicinal Chemistry, vol. 38, No. 8, 1995, pp. 1344-1354, ISSN: 0022-2623 (XP002314442).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 316474 1954 (XP0023922714).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 393777 1966 (XP002392715).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 5344832 1922 (XP002392716).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 7604813 1996 (XP002392717).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 8848189 2001 (XP002392718).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 7600437 1996 (XP002392719).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 5448817 1991 (XP002392720).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 6975717 1985 (XP002392721).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 7036362 1994 (XP002392722).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 410569 1971 (XP002392723).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 438575 1973 (XP002392724).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN622512 1974 (XP002392725).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN4209696 1990 (XP00239276).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 309332 1946 (XP002392727).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN 253307 1959 (XP002392728).
Database Beilstein, Beilstein Crossfire Institut Zur Foerderung Der Chemischen Wissenschaften, DE; BRN308560 1948 (XP002392729).
Database Chemcats, Chemical Abstracts Service, Columbus, Ohio, US; XP002307086, Order Nos. t0370-0639, t0369-0732. & “Ambinter Stock Screening Collection”, Jan. 1, 2004, Ambinter, 46 Quai Loius Bleriot, F-75016 Paris, France.
WO 03/103648A (Muto et al; Inst of Medicinal Molecular) Dec. 18, 2003, Abstract; & Database Chemabs ′Online! Chemical Abstracts Service Columbus, Ohio, US; XP002307087, retrieved from STN Database accession No. 140:27850 Abstract; and RN's 439144-91-9, 634185-05-0, 634185-10-7, 634185-14-1.
WO 03/103658A (Muto et al; Inst of Medicinal Molecular) Dec. 18, 2003, Abstract; & Database Chemabs ′Online! Chemical Abstracts Service, Columbus, Ohio, US; XP002307891, retrieved from STN Database accession No. 140:42204 Abstract; and RN's 439144-91-9, 634185-05-0, 634185-10-7, 634185-14-1.
Database Chemcats, Chemical Abstracts Service, Columbus, Ohio, US; XP002307088, Order No. CHS2296111. & “ChemStar Product List” Apr. 24, 2003, Chemstar Ltd, Leningradskii Prospekt 47, Office 465, Moskow, 125167, Russia.
Database Beilstein, Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE: XP002307089, Database Accession No. 290139 (BRN). & Chem. Ber., vol. 24, 1891, p. 2101.
Database Beilstein, Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002307090, Database Accession Nos. 1012247, 1257241, 1319746, 1322924 (BRN's). & J. Chem. Soc., 1963, pp. 4666-4669.
Database Beilstein, Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002307091, Database Accession Nos. 551856, 578613, 1257241, 1322924, 1324197 (BRN's). & J. Chem. Soc., 1964, p. 2609.
Database Beilstein, Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002307092, Database Accession Nos. 1601543, 2983204, 2982987 (BRN's). & J. Chem. Soc. C, 1969, pp. 1444-1448.
Database Beilstein, Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE; XP002307093,

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

C-fms kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with C-fms kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and C-fms kinase inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3981270

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.