Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1990-10-22
1993-06-01
Ellis, Joan
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 91, 4351723, 4352523, 43525233, 4352401, 435255, 435256, 4353201, 536 235, 530300, 735 6, 735 29, 735 41, 735 56, 735 61, 735 73, C12P 2102, C12P 1934, C12N 1500, C12N 500, C12N 121, C12N 116, C12N 118, A61K 3702, C07H 1512
Patent
active
052158926
ABSTRACT:
This invention relates to a gene which codes for the IL-6 gene expression inducing nuclear factor C/EBP2 capable of binding sequence-specifically to the palindrome structure SEQ ID NO:2 located in the transcriptional regulatory region of the IL-6 gene; an expression plasmid with the C/EBP2 gene incorporated therein; an transformant harboring the expression plasmid; a recombinant C/EBP2 obtained by expressing the C/EBP2 gene; and a method of producing the recombinant C/EBP2.
REFERENCES:
Akira, et al EMBO, J. vol. 9 pp. 1897-1906 (1990).
Landschulz et al Genes & Development vol. 2 pp. 786-800 (1988).
Mariahs et al Molecular Cloning A Laboratory Manual Cold Spring Harbor Laboratory CSH, N.Y. (1982).
Choquet, Y., et al, Cell, 52, 903-913 (1988).
Singh, H. et al, Cell 52, 415-423 (1988).
Akira Shizuo
Hirano Toshio
Isshiki Hiroshi
Kinoshita Shigemi
Kishimoto Tadamitsu
Ellis Joan
Tadamitsu Kishimoto
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