C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical c

Details C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical c C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical c

1984-07-18

1985-10-15

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 71, 549265, A61K 3170, C07H 1708, C07D49322

Patent

active

045474915

ABSTRACT:
There are disclosed novel avermectin and milbemycin compounds wherein the 8a position is oxidized to a ketone group. The 8a-oxo compounds are prepared by oxidizing an avermectin or milbemycin compound. The avermectin and milbemycin 8a-oxo compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests.

REFERENCES:
patent: 4199569 (1980-04-01), Chabala et al.
patent: 4200581 (1980-04-01), Fisher et al.
patent: 4289760 (1981-09-01), Mrozik et al.
patent: 4423209 (1983-12-01), Mrozik et al.
patent: 4427663 (1984-01-01), Mrozik

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