C-5 Substituted cytosine nucleosides

Details C-5 Substituted cytosine nucleosides C-5 Substituted cytosine nucleosides

1979-07-02

1981-05-12

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 23, A61K 3170, C07H 1700

Patent

active

042671710

ABSTRACT:
C-5 Substituted cytosine nucleosides wherein the C-5 substituent is substituted alkyl, alkenyl or substituted alkenyl; and the pharmaceutically acceptable acid addition salts thereof, are useful as antiviral agents. A novel process for the preparation of the subject compounds is also disclosed.

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patent: 3998807 (1976-12-01), Moffatt
Bergstrom, D. E., et al., J. Carbohydrates, Nucleosides, Nucleotides, vol. 4, 257-269 (1977).
Ruth, J. L., et al., J. Org. Chem., vol. 43, 2870-2876 (1978).
Bergstrom, D. E., et al., JACS, vol. 100, 8106-8112 (1978).
Wataya, Y., et al., J. of Medicinal Chem., vol. 22, 339 (1979).
Bergstrom et al., J. Am. Chem. Soc., vol. 98, 1587 (1976).
Kulikowski et al., J. Med. Chem., vol. 17, 269 (1974).

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