C-3 phosphine oxide substituted carbacephalosporins

Details C-3 phosphine oxide substituted carbacephalosporins C-3 phosphine oxide substituted carbacephalosporins

1991-04-25

1992-01-28

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

540205, C07D46300, C07F 9576, A61K 31675

Patent

active

050844474

ABSTRACT:
This invention provides novel 3-phosphine oxide substituted 1-carba(1-dethia)cephalosporins useful as anti-microbial agents, and formulations and methods of use thereof.

REFERENCES:
patent: 4291031 (1981-09-01), Takaya et al.
Nishide et al., Chem. Pharm. Bull. 36(7) 2354-2361 (1988), "A Synthesis of New 3-Dialkoxyphosphinylmethyl and 3-Dihydroxyphosphinylmethyl Cephalosporins".
Ziegler and Schwartz, J. Org. Chem., vol. 43, No. 5, 985-991 (1978), "Synthetic Studies on Lignan Lactones: Aryl Dithiane Route to (.+-.)-Podorhizol.sup.1 and (.+-.)-Isopodophyllotoxone and Approaches to the Stegane Skeleton".
Corbel et al., Synthesis 1048-1051, (1985), "An Efficient Synthesis of Dialkyl 2-Oxoalkanephonates and Diphenyl-2-Oxoalkylphosphine Oxides from 1-Chloralkyl Ketones".
Bhattacharya and Thyagarajan, Chem. Rev., vol. 81, No. 4, 415-430 (1981), "The Michaelis-Arbuzov Rearrangement".
Tavs and Weitkamp, Tetrahedron, vol. 26, 5529-5534, (1970), "Herstellung Und KMR-Spektren Einiger .alpha.,.beta.-Ungesattigter Phosphonsaureester Nickelsalzkatalysierte Reaktion Von Vinylhalogeniden Mit Trialkylphosphiten".

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