C-23-Modified derivatives of OMT, pharmaceutical compositions an

Details C-23-Modified derivatives of OMT, pharmaceutical compositions an C-23-Modified derivatives of OMT, pharmaceutical compositions an

1982-07-19

1984-07-10

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424181, 536 71, A61K 3171, C07H 1708

Patent

active

044592906

ABSTRACT:
C-23-Modified derivatives of 5-O-mycaminosyl-tylonolide (OMT) of the formula: ##STR1## wherein R is chloro, fluoro, --S--R.sup.4, azido, --NHR.sup.5, pyridinium, or --OSO.sub.2 CF.sub.3 ;

REFERENCES:
patent: 3459853 (1969-08-01), Gorman et al.
patent: 4252898 (1981-02-01), Nash et al.
patent: 4321361 (1982-03-01), Baltz et al.
patent: 4321362 (1982-03-01), Baltz et al.
patent: 4341770 (1982-07-01), Ose et al.
patent: 4341771 (1982-07-01), Kirst et al.
Tanaka et al., "Synthesis of 4'-Deoxymycaminosyl Tylonolide", J. Antibiotics 34 (10), 1374-1376 (1981).
Tanaka et al., "Synthesis of Derivatives of 4'-Deoxymycaminosyl Tylonolide and Mycaminosyl Tylonolide Modified at C-23", J. Antibiotics 34 (10(), 1377-1380 (1981).
Tanaka et al., "Syntheses of 23-Dialkylamino Derivatives of Mycaminosyl Tylonolide and 4'-Deoxymycaminosyl Tylonolide Effective Against Gram-Negative Bacteria", J. Antibiotics 35 (1), 113-116 (1982).
S. Omura, "Biosynthesis of 16-Membered Macrolide Antibiotics", Japan Antibiotics Research Association 224th Scientific Meeting, May 22, 1981.
Derwent Abstract No. 12994E of Japanese Unexamined Patent 7004-999 (ZH Biseibutsu Kagaku Ken), Jan. 11, 1982.
Derwent Abstract No. 12995E of Japanese Unexamined Patent 7005-000 (ZH Biseibutsu Kagaku Ken), Jan. 11, 1982.
Derwent Abstract No. 60702D/34 of European Patent 33-433 (Schering Corp.) Nov. 9, 1979.
Tanaka et al., "Syntheses of Recyclized Macrolide Antibiotics and Related Derivatives from Mycaminosyltylonolide", Bull. Chem. Soc. Jpn., 54, 3837-3845 (1981).
Matsubara et al., "Chemical Transformation of Tylosin, a 16-Membered Macrolide and its Structure-Activity Relationship", Chem. Pharm. Bull. 30 (1), 97-110 (1982).

Affiliated with

Also associated with

Rating

C-23-Modified derivatives of OMT, pharmaceutical compositions an does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with C-23-Modified derivatives of OMT, pharmaceutical compositions an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and C-23-Modified derivatives of OMT, pharmaceutical compositions an will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1576137