C-23-Modified derivatives of DMT

Details C-23-Modified derivatives of DMT C-23-Modified derivatives of DMT

1982-07-19

1984-06-05

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424181, 536 71, A61K 3170, C07H 1708

Patent

active

044527845

ABSTRACT:
C-23-Modified derivatives of demycinosyltylosin (DMT) of the formula: ##STR1## wherein R is iodo, bromo, chloro, fluoro, --S--R.sup.4, azido, --NHR.sup.5, pyridinium or --OSO.sub.2 CF.sub.3 ;

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patent: 4304856 (1981-12-01), Baltz et al.
patent: 4321361 (1982-03-01), Baltz et al.
patent: 4321362 (1982-03-01), Baltz et al.
patent: 4341770 (1982-07-01), Ose et al.
patent: 4341771 (1982-07-01), Kirst et al.
patent: 4358584 (1982-11-01), Nash et al.
Tanaka et al., "Synthesis of 4'-Deoxymycaminosyl Tylonolide," J. Antibiotics 34 (10), 1374-1376 (1981).
Tanaka et al., "Synthesis of Derivatives of 4'-Deoxymycaminosyl Tylonolide and Mycaminosyl Tylonolide Modified at C-23," Ibid 34 (10), 1377-1380 (1981).
Tanaka et al., "Syntheses of 23-Dialkylamino Derivatives of Mycaminosyl Tylonolide and 4'-Deoxymycaminosyl Tylonolide Effective Against Gram-Negative Bacteria," Ibid 35 (1), 113-116 (1982).
S. Omura, "Biosynthesis of 16-Membered Macrolide Antibiotics," Japan Antibiotic Research Association 224th Scientific Meeting, May 22, 1981 (notes from talk).
Derwent Abstract No. 12994E of Japanese Unexamined Patent 7004-999 (ZH Biseibutsu Kagaku Ken), Jan. 11, 1982.
Derwent Abstract No. 12995E of Japanese Unexamined Patent 7005-000 (ZH Biseibutsu Kagaku Ken), Jan. 11, 1982.
Derwent Abstract No. 60702D/34 of European Patent 33-433 (Schering Corp.) Nov. 9, 1979.
Tanaka et al., "Syntheses of Recyclized Macrolide Antibiotics and Related Derivatives from Mycaminosyltylonolide", Bull. Chem. Soc. Jpn., 54, 3837-3845 (1981).
Matsubara et al., "Chemical Transformation of Tylosin, a 16-Membered Macrolide, and Its Structure-Activity Relationship", Chem. Pharm. Bull. 30 (1), 97-110 (1982).

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