C-22 ring stabilized rapamycin derivatives

Details C-22 ring stabilized rapamycin derivatives C-22 ring stabilized rapamycin derivatives

1993-08-10

1995-02-07

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540452, C07D49106, A61K 31395

Patent

active

053876806

ABSTRACT:
This invention provides C-22 substituted rapamycin derivatives of the following formulas: ##STR1## and pharmaceutically acceptable salts thereof which are useful for inducing immunosuppression and treating transplantation rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, solid tumors, fungal infections, adult T-cell leukemia/lymphomas and hyperproliferative vascular disorders.

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