C-20-Modified macrolide derivatives of the macrolide antibiotics

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...

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536 71, A61K 3171, C07H 1708

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active

044434367

ABSTRACT:
C-20-Modified derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, lactenocin, 2"'-O-demethylmacrocin and 2"-O-demethyllactenocin inhibit pathogenic bacteria, especially gram-positive bacteria, Pasteurella species, and Mycoplasma species and pharmaceutical compositions thereof.

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Matsubara et al., "Chemical Transformation of Tylosin, a 16-Membered Macrolide and its Structure-Activity Relationship", Chem. Pharm. Bull. 30 (1), 97-110 (1982).
S. Omura et al., "Novel Dimeric Derivatives of Leucomycins and Tylosin, Sixteen-Membered Macrolides", J. Med. Chem. 25, 271-275 (1982).
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A. Tanaka et al., "Syntheses of 4'-Deoxy-Demycarosyl Tylosin and Its Analogues", J. Antibiotics 34 (10), 1381-1384 (1981).
S. Satoi et al., "Mycinamicins, New Macrolide Antibiotics. I: Taxonomy, Production, Isolation, Characterization and Properties", J. Antibiotics 33 (4), 364-377 (1980).

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