C-20- And C-23-Modified macrolide derivatives

Details C-20- And C-23-Modified macrolide derivatives C-20- And C-23-Modified macrolide derivatives

1983-02-28

1984-08-28

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1708

Patent

active

044685114

ABSTRACT:
C-20- and C-23-Modified macrolide derivatives of demycinosyltylocin (DMT), 5-O-mycaminosyltylonolide (OMT) 23-de(mycinosyloxy)tylosin, 23-deoxy-OMT, 20-dihydro-20-deoxy-DMT and 20-dihydro-20-deoxy-OMT are useful antibiotics or intermediates to antibiotics.

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H. Matsubara et al., "Chemical Transformation of Tylosin, a 16-Membered Macrolide, and its Structure-Activity Relationship", Chem. Pharm. Bull., 30 (1), 97-110 (1982).
S. Omura et al., "Novel Dimeric Derivatives of Leucomycins and Tylosin, Sixteen-Membered Macrolides", J. Med. Chem. 25, 271-275 (1982).
Derwent Abstract No. 71396Y of Japanese Unexamined Patent 2100-485 (Takeda), Aug. 23, 1977.
A. Tanaka et al., "Syntheses of 4'-Deoxy-Demycarosyl Tylosin and its Analogues", J. Antibiotics 34 (10), 1381-1384 (1981).
S. Satoi et al., "Mycinamicins, New Macrolide Antibiotics, I: Taxonomy, Production, Isolation, Characterization and Properties", J. Antibiotics 33 (4), 364-377 (1980).
A. Tanaka et al., "Syntheses of 23-Dialkylamino Derivatives of Mycaminosyl Tylonolide and 4'-Deoxymycaminosyl Tylonolide Effective Against Gram-Negative Bacteria", J. Antibiotics 35 (1), 113-116 (1982).
A. Tanaka et al., "Synthesis of 4'-Deoxymycaminosyl Tylonolide", J. Antibiotics 34 (10), 1374-1376 (1981).
A. Tanaka et al., "Synthesis of Derivatives of 4'-Deoxymycaminosyl Tylonolide and Mycaminosyl Tylonolide Modified at C-23", J. Antibiotics 34 (10), 1377-1380 (1981).
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