C-20- and C-23 modified macrolide derivatives

Details C-20- and C-23 modified macrolide derivatives C-20- and C-23 modified macrolide derivatives

1984-05-25

1986-12-16

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1708

Patent

active

046297863

ABSTRACT:
C-20-Modified derivatives of macrolide antibiotics which include demycinosyltylosin (DMT), 20-dihydro-23-demycinosyltylosin (dihydro-DMT), 23-de(mycinosyloxy)tylosin (DMOT), 20-dihydro-23-de(mycinosyloxy)tylosin (dihydro-DMOT), 5-O-mycaminosyltylonolide (OMT), 20-dihydro-5-O-mycaminosyltylonolide (dihydro-OMT), 23-deoxy-5-O-mycaminosyltylonolide (DOMT), and 20-dihydro-23-deoxy-5-O-mycaminosyltylonolide (dihydro-DOMT) inhibit pathogenic bacteria, especially gram-positive bacteria, and Mycoplasma species; and pharmaceutical compositions thereof.

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