C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substitu

Details C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substitu C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substitu

1999-06-21

2000-10-24

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 23, 560 42, 549510, 549511, C07C22908, C07D30514

Patent

active

061369993

ABSTRACT:
A chemical compound having the formula: ##STR1## wherein P.sub.1 is a hydroxyl protecting group, R.sub.1 may be H or electron withdrawing group, R.sub.2 may be H or electron withdrawing group, R.sub.3 may be H or electron withdrawing group, R.sub.4 may be H or electron withdrawing group, R.sub.5 may be H or electron withdrawing group, R.sub.6 may be an alkyl group, an olefinic group, an aromatic group, Ph, PhCH.sub.2, an O-alkyl group, an O-olefinic group, an O-aromatic group, O--Ph, or O--CH.sub.2 Ph.

REFERENCES:
patent: 4924011 (1990-05-01), Denis et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 5015744 (1991-05-01), Holton
patent: 5229526 (1993-07-01), Holton
patent: 5274124 (1993-12-01), Holton
patent: 5675025 (1997-10-01), Sisti et al.
patent: 5684175 (1997-11-01), Sisti et al.
patent: 5688977 (1997-11-01), Sisti et al.
patent: 5750736 (1998-05-01), Sisti et al.
patent: 5750737 (1998-05-01), Sisti et al.
patent: 5770745 (1998-06-01), Swindell et al.
"Highly Efficient, Practical Approach to Natural Taxol", Denis et al, Journal of the American Chemical Society, p. 5917 (1988) Greene and Gueritte-Voegelein, J. Am. Chem. Soc., 1988, 110, 5917.
"A Chemoselective Approach to Functionalize the C-10 Position of 10-deacetyl baccatin III. Synthesis and Biological Properties of Novel Taxol Analogs", Kant et al., Tetrahedron Letters, vol. 35, No. 31, 1994, p. 5543.

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