Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-12-30
2000-12-05
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514 85, 514253, 514338, 544375, 5462817, 549208, 549348, A61K 31335, C07D49318
Patent
active
061567906
ABSTRACT:
The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.
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Daughenbaugh Randall J.
Murray Christopher
Parker Michael H.
Ploypradith Poonsakdi
Posner Gary H.
Dentz Bernard
Hauser, Inc.
Johns Hopkins University
O'Rourke Sarah
Petersen Steven C.
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