C-10 analogs of huperzine a

Details C-10 analogs of huperzine a C-10 analogs of huperzine a

1994-09-07

1996-08-20

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 79, A61K 3144, C07D22106, C07D22122

Patent

active

055479600

ABSTRACT:
The present invention provides C.sup.10 -mono- and disubstituted analogs of huperzine A which are active as acetylcholinesterase inhibitors, as well as intermediates for the preparation thereof.

REFERENCES:
patent: 4929731 (1990-05-01), Kozikowski et al.
patent: 5104880 (1992-04-01), Kozikowski
patent: 5106979 (1992-04-01), Kozikowski et al.
patent: 5177082 (1993-01-01), Yu et al.
Y. Ashani et al., "Role of Tyrosine 337 in the Binding of Huperzine A to the Active Site of Human Acetylcholinesterase", Molecular Pharmacology, 45, 555-560 (Mar. 1994).
J. R. Atack et al., "Comparative Inhibitory Effects of Various Physostigmine Analogs against Acetyl- and Butyrylcholinesterases", J. Pharmacol. Exp. Ther., 249, 194-202 (1989).
W. A. Ayer et al., "Some new Lycopodium alkaloids", Can. J. Chem., 67, 1077-1086 (Jun. 1989).
W. A. Ayer et al. "Alkaloids of Lycopodium selago. On the identity of sealgine with hupertine A and the structure of a related alkaloid", Can. J. Chem., 67, 1538-1540 (Oct. 1989).
S. Chen et al., "The effect of fordine on learning and memory in rats", Chem. Abs., 108, Abstract No. 143270x (1988).
Y. S. Cheng, "128 cases of myasthenia gravis treated with huperzine A", New Drugs and Clinical Remedies, 5, 197-199 (1986)-English Language Abstracts included on last page.
D. Gravel et al., "Novel Palladium Catalyzed Bicycloannulation of Monoactivated Cyclic Ketones Using a 1, 3-Allylic Diacetate and an Enolysing Catalyst", Tetrahedron Letters, 33, 1407-1410 (1992).
A. P. Kozikowski, "Synthetic Chemistry, Neurotransmission and Second Messengers", J. Heterocyclic Chem., 27, 97-105 (Jan. 1990).
J. Liu et al., "Chemistry of huperzine A and B", Chem. Abs., 1 107, Abstract No. 115821p (1987).
J. S. Liu et al., "The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity", Can. J. Chem., 64, 837-839 (Apr. 1986).
X. Tang et al., "Effects of huperzine A on learning and retrieval process of discrimination performance in rats", Chem. Abs., Abstract No. 12878n (1987).
X.-C. Tang et al., "Effects of huperzine A on learning and retrieval process of discrimination performance in rats", Acta Pharmacol. Sinica, 7, 507-511 (Nov. 1986)-English Language Abstract included on last page.
X.-C. Tang et al., "Effects of Huperzine A, a New Cholinesterase Inhibitor, on the Central Cholinergic System of the Rat", J. Neurosci. Res., 24, 276-285 (1989).
G. P. Vincent et al., "the Effects of Huperzine A, An Acetylcholinesterase Inhibitor, on the Enhancement of Memory in Mice, Rats and Monkeys", Neurosci. Abst., 13, 884, Abstract No. 237.4 (1987).
R. J. Wurtman, "Alzheimer's Disease", Scientific Amer., 62-66, 71-74 (1985).
Y. Xia et al., "Synthesis of the Benzenoid Analogue of the Chinese Nootropic Agent Huperzine A", Tetrahedron Letters, 30, 3291-3294 (1989).
Y. Xia et al., "A Practical Synthesis of the Chinese Nootropic Agent Huperzine A: A Possible Lead in the Treatment of Alzheimer's Disease", J. Am. Chem. Soc., 111, 4116-4117 (1989).

Affiliated with

Also associated with

Rating

C-10 analogs of huperzine a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with C-10 analogs of huperzine a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and C-10 analogs of huperzine a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2330945