Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-07-10
2007-07-10
Owens, Amelia A. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C549S396000
Reexamination Certificate
active
11300966
ABSTRACT:
The present invention relates to bicyclic tetrahydrofuran derivatives of Formula (1) and a preparation method thereof, and particularly it relates to a process of preparing compounds of Formula (1) by performing an intramolecular cyclization of tetrahydrofuran-allenol derivatives in the presence of alcohol compound, transitional metal catalyst and carbon monoxide:wherein n is 1 or 2; R is phenyl optionally substituted with C1-C6alkyl, C1-C6alkoxy, hydroxyl or C1-C6hydroxyalkyl group; and R1is C1-C6alkyl group.
REFERENCES:
patent: 2007/0010679 (2007-01-01), Cho et al.
Masayuki, Sataki, Azaspiracid, a New Marine Toxin Having Unique Spiro Ring Assemblies, Isolated from Irish Mussels,Mytilus edulis, J. Am. Chem. Soc., 1998, 120, 9967-9968.
Josep Aiguade, Synthesis of a 2,9-Dioxabicyclo[3..3.1]nonane via Double Intramolecular Hetero-Michael Addition: Entry to the F-G Ring System of the Azaspiracids, Org. Lett., 2001, 3, 979-982.
K.C. Nicolaou, Synthesis of the FGHI Ring System of Azaspiracid, Angew. Chem., Int. Ed. 2001,40, 1262-1265.
Stephen Hanessian, Total Synthesis and Structural Confirmation of Malayamycin A: A Novel Bicyclic C-Nucleoside fromStreptomyces malaysiensis, Org. Lett., 2003, 23, 4277-4280.
Cha Joo Hwan
Cho Yong Seo
Koh Hun Yeong
Pae Ae Nim
Shin Chul
Frommer & Lawrence & Haug LLP
Korea Institute of Science and Technology
Owens Amelia A.
Santucci Ronald R.
LandOfFree
Bycyclic tetrahydrofuran derivatives and process for the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bycyclic tetrahydrofuran derivatives and process for the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bycyclic tetrahydrofuran derivatives and process for the... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3814440