Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2006-05-23
2006-05-23
Saidha, Tekchand (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S197000, C435S252300, C435S320100, C435S325000, C536S023200
Reexamination Certificate
active
07049121
ABSTRACT:
The invention provides twenty-one butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
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Accession No. P06276 and SEQ ID No.: 2 sequence search alignment.
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Pancook James D
Watkins Jeffry D
Applied Molecular Evolution
Davis Paula K.
Saidha Tekchand
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