Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-07-14
1998-06-23
Kumar, Shailendra
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514561, 562573, 564153, 564158, 564159, A61K 3116, C07C23305
Patent
active
057706255
ABSTRACT:
The present invention provides a compound having the structure: ##STR1## wherein R.sub.1 is hydrogen or a branched or unbranched, substituted or unsubstituted aminoalkyl having from two to twenty atoms in the chain, R.sub.2 is hydrogen, methyl, or a branched or unbranched, substituted or unsubstituted alkyl having from two to twenty atoms in the chain; when R.sub.2 is methyl, R.sub.3 is either hydrogen or a substituted or unsubstituted aryl; and R.sub.4 is methyl, a branched or unbranched, substituted or unsubstituted alkyl, alkenyl, alkynyl, alkenynyl, or cycloalkyl having from two to twenty atoms in the chain, or a substituted or unsubstituted aryl group.
The invention also concerns a method of preparing the compound from the venom, venom sacs or venom glands of the wasp Philanthus triangulun F. Additionally, the invention provides a method of chemically synthesizing the compound.
Another aspect of the invention concerns a method of treating a subject afflicted by a disorder associated with binding of an etiological agent to a glutamate receptor. Lastly, the invention provides an insecticidal composition which comprises an effective amount of the compound and a suitable carrier and a method of combatting insects which comprises administering to the insects the insecticidal composition.
REFERENCES:
patent: 4956504 (1990-09-01), Takeuchi et al.
patent: 5218000 (1993-06-01), Usherwood et al.
Teshima et al., Tetrahedron Letters, vol. 28, No. 30, pp. 3509-3510, 1987.
Adams et al., Biochemical & Biophysical Research Communication, vol. 148, No. 2, 1987, 678-683.
Kawai et al, Neurotransmitters, Focus on Excitatory Amino Acids, Excerpta Medica, 1988, 31-42.
Eldefrawi Amira T.
Eldefrawi Mohyee E.
Nakanishi Koji
Usherwood Peter N. R.
Kumar Shailendra
The Trustees of Columbia University in the City of New York
White John P.
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