Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-10-06
1999-03-16
Mullis, Jeffrey C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514529, 514546, 514547, A61K 31215, A61K 3122
Patent
active
058831231
ABSTRACT:
This invention relates to butyrate prodrugs derived from lactic acid and pharmaceutical compositions and methods employing them, either alone or in combination with other agents, for increasing gamma globin and fetal hemoglobin in a patient. These compounds, compositions and methods are particularly effective in treating .beta.-hemoglobinopathies, including sickle cell syndromes and .beta.-thalassemia syndromes. In addition, this invention relates to the use of these prodrugs, alone or in combination with other agents, to stimulate cell differentiation which prevents proliferation of malignant cells. These methods are particularly useful in treating cancer, especially malignant hematological disorders.
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Li Biqin
Tung Roger D.
Haley, Jr. James F.
Mullis Jeffrey C.
Pierri Margaret A.
Vertex Pharmaceuticals Inc.
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