Butylene oxide-ethylene oxide block copolymer surfactants as sta

Details Butylene oxide-ethylene oxide block copolymer surfactants as sta Butylene oxide-ethylene oxide block copolymer surfactants as sta

1994-06-28

1996-12-24

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

424497, 424 9455, 424 945, A61K 4900, A61K 4904

Patent

active

055871437

ABSTRACT:
This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a nonionic polymeric surfactant as a surface modifier adsorbed on the surface thereof, the surfactant being a block copolymer of ethylene oxide and butylene oxide and a method of making such nanoparticles. The compositions exhibit reduced macrophage uptake and improved toxicological profiles and facilitate particle size reduction such that milling time can be reduced and/or sterile filtration of the nanoparticles can be accomplished.

REFERENCES:
patent: 4535545 (1985-08-01), Sebag
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5318767 (1994-06-01), Liversidge et al.
patent: 5369131 (1994-11-01), Poli et al.
patent: 5393519 (1995-02-01), Dowell et al.
U.S. pat. application Ser. No. 07/988,564 filed Dec. 10, 1992.
B-Series Polyglycols by Dow.

Affiliated with

Also associated with

Rating

Butylene oxide-ethylene oxide block copolymer surfactants as sta does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Butylene oxide-ethylene oxide block copolymer surfactants as sta, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Butylene oxide-ethylene oxide block copolymer surfactants as sta will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1177006