Butenoic acid derivatives, pharmaceutical compositions containin

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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C07C 6976

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active

047629444

ABSTRACT:
The invention relates to novel butenoic acid derivatives of the general formula (Ia) having E-configuration ##STR1## as well as to their Z-izomers of the general formula ##STR2## wherein R stands for a (-)-menthyl or a (+)-menthyl group. as well as pharmaceutical compositions containing these compounds.
The novel butenoic acid derivatives of the general formulae (Ia) and (Ib) possess valuable pharmacological properties, mainly gastric cytoprotective effect.

REFERENCES:
Bowden, K. J. Chem. Soc. B (1)156-160 1971; CA74(13); 63664t.
Bowden, K et al., Advan. Chem. Ser. 114(Biol Correl-Hansch Approach Lymp.)139-140, 1972 CA78(13): 80361S.
Anderson et al, Biochem. Biophys. Acta 703(2), 204-211, 1982, CA 97(1)2728 V.

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