Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1984-11-21
1992-02-18
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514554, 564320, 564324, A61K 31135, C07C21508
Patent
active
050895290
ABSTRACT:
4-mono- and di-isobutylamino butanols of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.1 and R.sup.2 are the same or different and each is selected from the group consisting of hydrogen, halo, hydroxyl, alkyl of 1 to 4 carbon atoms and alkoxy of 1 to 4 carbon atoms and R is hydrogen or isobutyl, are useful for the treatment of circulatory disorders, particularly arrhythmias, in humans and animals.
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patent: 3190920 (1985-06-01), Spickett et al.
patent: 3441602 (1969-04-01), Hollinger et al.
Barton et al., "Synthetic Analgesics", Part I, Diphenylpropylamines, vol. 3, pp. 110-114 (1960).
Wolf, "Burgar's Medicinal Chemistry", 4th ed., Part III, pp. 84-89 (1979).
Kimura Kiyoshi
Morita Iwao
Murakami Tetsuo
Yamaguchi Takeshi
Nippon Shinyaku Co. Ltd.
Raymond Richard L.
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