Busulfan immunoassay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Details

C435S007920, C435S007930, C435S810000, C435S961000, C435S974000, C436S518000, C436S534000, C436S815000, C530S389800, C530S501000, C564S511000

Reexamination Certificate

active

07148024

ABSTRACT:
Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids.

REFERENCES:
patent: 5430057 (1995-07-01), Andersson et al.
Lai et al. Routine analysis of plasma busulfan by gas chromatography-mass fragmentography. Clinical Chemistry 1998, vol. 44, Issue 12, pp. 2506-2510.
Reis et al. Development of a rapid and specific assay for detection of busulfan in human plasma by high-performance liquid chromatography/electrospray ionization tandem mass spectometry. Rapid Communicaiton in Mass Spectrometry. 2004, vol. 19, pp. 1666-1674.
Murdter et al. Sensitive and rapid quantification of busulfan in small plasma volumes by liquid chromatography-electrospray mass spectrometry. 2001 Clinical Chemistry, vol. 47, Issue 8, pp. 1437-1442.
Murdter et al. Sensitive and rapid quantification of Busulfan in small plasma volumes by liquid chromatography electrospray mass spectrometry. Clinical Chemistry 2001, vol. 47, pp. 1437-1442, whole document.
Lai et al. Routine analysis of plasma busulfan by gas chromatography-mass freagmentography, Clinical Chemistry 1998, vol. 44, pp. 2506-2510, whole document.

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