Burn and wound ointment

Details Burn and wound ointment Burn and wound ointment

1998-11-10

1999-12-07

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

424443, 424DIG13, 514886, 514969, A61K 3578, A61K 906

Patent

active

059978767

DESCRIPTION:

BRIEF SUMMARY
This invention refers to the sphere of medicine, in particular to pharmaceutics and concerns the preparations for bum treatment.
There is known calendula ointment Unguentum "Calendula", which contains tincture of calendula (on 70% spirit 1:10)--20 g, vaseline--90 g: [Mashkovskij M. V. "Medicinal Means", Moscow, "Medicine" 1986, vol. 2, p. 2.424].
At using this ointment on wound and burn the process of healing is slowed down, as the ointment contains only one medicinal preparation and vaseline. vaseliine makes crust on the injured surface, under which the microbes are easily reproduced.
There is also known "Ointment Kolkhuri", which contains St.John's-wort. the oak bark, haw-thom, yarrow, yellow melilot, horse-chestnut 0.06-0.065 in equal quanity, nettle 0.10-0.11, gum-tree extract 0.02, belladonna extract 0.02, vaseline--the rest; [GE 13, Darsania, V. 15.05.94].
This ointment is used as analgetic and antiinflammatory means and is less effective for healing the wounds and burns, as haw-thorn and belladonna arc not characterized by antiinflammatory and regeneration stimulating effect. The yellow melilot and horse-chestnut contain substances which hinder the blood coagulation and do not effect the skin regeneration. The oak bark and nettle have antiinflammatory properties, but it must be mentioned, that tannin involved in oak bark in reaction with the injured surface mucous membrane proteins at burn makes a coat, under which purulent process occurs. The nettle increases the quantity of erythrocytes and hemoglobin, which is raised at burn in result of intensified loss of plasma.
The technical result of the present invention is in widening the assortment of medicinal preparations for treatment of burns and wounds, in increasing treatment effect.
The technical result is achieved by that the green ointment, which contains St.John's-wort, yarrow, gum-tree, additionally contains celandine, plantain, matricary, calendula, olive oil and yellow wax of honey in the following relation of components in mass parts:


______________________________________ celandine Chelidonium majus 15-25 g plantain Plantago major 15-25 g matricary Matricaria chamomilla 15-25 g yarrow Achillea millefolium 15-25 g calendula Calendula officinalis 15-25 g St. John's-wort Hypericum perforatum 15-25 g gum-tree Eucalyptus globulus 15-25 g olive oil Oleum olivarum 1000 g yellow wax of honey Cera flava 80-130 g ______________________________________
The additional application of celandine, plantain, matricary, calendula, olive oil and yellow wax of honey in the ointment in the said relation of components in mass parts enables to increase treatment effect, which is provided by the properties of the grass.
Celaudine--is characterized by antiinflammatory, local analgetic, regeneration accelerating effect.
Plantain--is characterized by antimicrobic, hemostasia and wound healing effect.
Matricary--is characterized by antiseptic, local analgetic and antiinflammatory effect, accelerates regeneration.
Calendula--strengthens the circulatory vessels walls, reduces their permeability, what is very important at burn, when the capillary conduction and plasinorrhea is increased. Calendula's effect grows in combination with matricary and yarrow, skin epitalization and granulation, local protective mechanisms increase.
Olive oil--has deeper effect than the vaseline, the skin absorbs it easily.
Honey wax--contains large quantity of vitamin A, which is necessary, for recovery of skin entirety and provides for fast healing of the burn.
Besides, the increase of the quantify of celandine, plantain, matricary, calendula. yarrow, St.John's-wort, gum-tree in green ointment more than 25 g, of the olive oil more than 1000 g and of the honey yellow wax more than 130 g doesn't promote the treatment efficiency and results in over-expenditure of the raw.
At the same time the reduction of the quantity of celandine, plantain, matricary, calendula, yarrow, St.John's-wort, gum-tree below 15 g, of the olive oil below 1000 g and of the honey

REFERENCES:
patent: 4459285 (1984-07-01), Grollier et al.
patent: 5061491 (1991-10-01), Deryabin
Database Derwent Publications, No. 97-049981, Leontev et al. `Balsam composition with wound-healing properties comprising camphor, essential oil concentrate containing oil from mint and one other plant, and herb mixture edible oil extract,` abstract, Make, Jan. 1995.
Database Derwent Publications, No. 95-342794, Purakhina et al. Anitbacterial cream for persona saintary use contains dry extracts of St. John's Wort and bur marigold, yarrow grass and calendula flowers, liquorice root, sea buckthorn berries, and ointment, Mar. 1995.
Database Derwent Publications, No. 96-107601, `Preparation of dermatology cream type cerate comprises thermostated agitated blending of plant fractions, e.g. Chelidonium majus and Plantago lanceolata,` Soria Natural SA, Jan. 1996.

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