Buoyant controlled release powder formulation

Details Buoyant controlled release powder formulation Buoyant controlled release powder formulation

1991-10-23

1992-12-08

Page, Thurman A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424452, 424488, 424489, 424499, 514779, 514781, 514962, 514964, 514951, A61K 952

Patent

active

051696380

ABSTRACT:
A buoyant controlled release pharmaceutical powder formulation is provided which may be filled into capsules and releases a pharmaceutical of a basic character at a controlled rate regardless of the pH of the environment, which formulation includes a basic pharmaceutical, up to about 45% by weight of a pH dependent polymer which is a salt of alginic acid, such as sodium alginate, up to about 35% by weight of a pH-independent hydrocarbon gelling agent having a viscosity of up to about 100,000 centipoises in 2% solution at 20.degree. C. and excipients.

REFERENCES:
patent: 4101650 (1978-07-01), Umezawa
patent: 4140755 (1979-02-01), Sheth et al.
patent: 4167558 (1979-09-01), Sheth et al.
patent: 4702918 (1987-10-01), Ushimaru et al.
patent: 4792452 (1988-12-01), Howard et al.
patent: 4814178 (1989-03-01), Bolton et al.
patent: 4814179 (1989-03-01), Bolton et al.
Stockwell et al., In Vitro Evaluation of Alginate Gel System as Sustained Release Drug Delivery Systems, Journal Controlled Release, 3, (1986), pp. 167-175.
"Gel formation with Alginate", Data Sheet D1571, Alginate Industries Limited, London.
Ingani et al., Int. J. Pharm., 35, 157-164 (1987).
J. Timmermans, A. J. Moes, Int. J. Pharm., 62, 207-216 (1990).

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