Drug – bio-affecting and body treating compositions – Dentifrices – Fluorine or fluorine compound containing
Patent
1991-10-25
1993-06-01
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
Fluorine or fluorine compound containing
424 49, 424 57, 424717, A61K 716, A61K 718, A61K 3310
Patent
active
052157407
ABSTRACT:
A dentifrice for inhibiting calculus formation, comprising sodium bicarbonate, one or more alkali metal pyrophosphate salts, a soluble fluoride ion source and other adjuvants, in admixture with a buffering agent selected from among an alkali metal orthophosphate, o-phosphoric acid, an alkali metal glycerophosphate, tri(hydroxymethyl)aminomethane, tartaric acid or citric acid. The buffering agent is incorporated in the dentifrice in an amount of from about 0.1 to 2.5% by weight, sufficient to buffer the pH of the dentifrice to a value within the range of from about pH 8.2 to 8.9. The thus buffered dentifrice is subject to decreased risk of irritation of the oral mucosa or desquamation, as compared with dentifrices excluding such a buffering agent.
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Domke Todd W.
Hauschild John P.
Cave Bryan
Church & Dwight & Co., Inc.
Rose Shep K.
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