Buffered matrix aspirin

Details Buffered matrix aspirin Buffered matrix aspirin

1995-06-05

1996-11-19

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424480, 424482, 424484, 424486, 424494, 424497, A61K 936

Patent

active

055760244

ABSTRACT:
A buffered aspirin tablet composed of a uniform mixture of aqueous-based polymer coated aspirin, a buffering system and a hydrophillic gel-forming matrix material. The buffering system and matrix material provide a microenvironment on in vitro dissolution of about pH 5. The tablet does not require the use of multilayers and may be prepared by direct compression with conventional equipment.

REFERENCES:
patent: 3341416 (1967-09-01), Anderson et al.
patent: 3946110 (1976-03-01), Hill
patent: 4153677 (1979-05-01), John
patent: 4369172 (1983-01-01), Schor et al.
patent: 4555399 (1985-11-01), Hsiao
patent: 4869984 (1989-09-01), Patel
patent: 4970081 (1990-11-01), Frisbee
Van Nostrand Reinhold Encyclopedia of Chemistry 4th edition, pp. 149-150 (1984).

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